Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 6 Articles
Background: Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading\nto unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN\npatients and healthy controls.\nMethods: In this study DLG1-AS1 and miR-199a-3p in plasma of both PTC patients and BTN patients were detected\nby qPCR. ROC curve analysis was performed for diagnostic analysis. Overexpression experiments were performed to\nanalyze the interaction between DLG1-AS1 and miR-199a-3p. CCK-8 assay was performed to analyze cell\nproliferation.\nResults: In this study, upregulation of DLG1-AS1 distinguished PTC patients from BTN patients and healthy controls.\nPlasma miR-199a-3p was downregulated in PTC patients compared with healthy controls and BTN patients. Plasma\nlevels of miR-199a-3p were inversely correlated in PTC patients, but not in BTN patients and healthy controls. miR-\n199a-3p overexpression failed to significantly affect DLG1-AS1, while DLG1-AS1 overexpression resulted in\ndownregulated miR-199a-3p, In addition, DLG1-AS1 overexpression promoted the proliferation of PTC cells. miR-\n199a-3p overexpression played an opposite role and attenuated the effects of DLG1-AS1 overexpression....
Background: To investigate the risk factors of cervical lymph node (LN) metastasis in papillary thyroid microcarcinoma\n(PTMC) patients.\nMethods: We retrospectively analyzed the clinicopathologic data of all patients who received standard lobectomy\nfor PTMC at our institution between October 2017 and January 2019. Central LNs were dissected in all patients. Lateral\nLNs were dissected if metastasis to the lateral LNs was suggested based on pre-op fine-needle aspiration biopsy. The\nrelationship between variables available prior to surgery and cervical LN metastasis was examined using multivariate\nregression.\nResults: Post-op pathologic examination revealed cervical LN metastasis in 79 (29.5%) patients. Seventy subjects had\nmetastasis only to central LNs, and 4 (1.5%) patients had metastasis only to lateral LNs. Five patients had metastasis to\nboth central and lateral LNs...........................................
Background: The present study aimed to investigate the prognostic significance of preoperative main pancreatic\nduct dilation and the neutrophil-to-lymphocyte ratio (PD-NLR) in pancreatic neuroendocrine tumors (PNETs) of the\nhead after curative resection.\nMethods: Sixty-four consecutive PNETs of the head that underwent curative resection were included in the study.\nPreoperative main pancreatic duct dilation (PD) was defined as a pancreatic duct dilation greater than 3mm before\nsurgery. Patients with both PD and an elevated NLR (> 3.13), with PD or elevated NLR, or neither of these characteristics\nwere allocated a PD-NLR score of 2, 1, or 0, respectively. Univariate, multivariate and Kaplan-Meier analyses were used\nto calculate overall survival (OS) and disease-free survival (DFS).\nResults: Preoperative PD-NLR score was correlated with tumor size (P = 0.005), T-stage (P = 0.016), lymph node\nmetastasis (P < 0.001), distant metastasis (P = 0.005), type of hormone production (P = 0.006), perineural invasion (P = 0.014),\nand WHO classification (P < 0.001). Patients with a high PD-NLR score had a significantly poor OS and DFS relative to those\nwith a low PD-NLR score (P < 0.001). In the multivariate analysis, PD-NLR score was an independent predictor of OS and\nDFS for PNET of the head (both P < 0.05). In the analyses of the various subgroups, preoperative PD-NLR score was also a\npredictor of OS and DFS. Additionally, the survival predictive capability of PD-NLR score was superior to that of WHO\nclassification.\nConclusions: Despite the retrospective nature and small sample size of the present study, the results suggest that\npreoperative PD-NLR score can serve as an independent prognostic marker of early survival in patients with PNETs of the\nhead undergoing curative resection. Further large prospective studies are necessary to validate our findings....
Background: Diabetes is 7th largest cause of death worldwide, and prevalence is increasing rapidly in low-and\nmiddle-income countries. There is an urgent need to develop and test interventions to prevent and control diabetes and\ndevelop the theory about how such interventions can be effective. We conducted a participatory learning and action (PLA)\nintervention with community groups in rural Bangladesh which was evaluated through a cluster randomised controlled trial.\nThere was a large reduction in the combined prevalence of type 2 diabetes and intermediate hyperglycaemia in the PLA\ngroup compared with the control group. We present findings from qualitative process evaluation research to explore how\nthis intervention was effective.\nMethods: We conducted group interviews and focus group discussions using photovoice with purposively sampled group\nattenders and non-attenders, and intervention implementers. Data were collected before the trial analysis. We used inductive\ncontent analysis to generate theory from the data.\nResults: The intervention increased the health literacy of individuals and communities - developing their\nknowledge, capacity and self-confidence to enact healthy behaviours. Community, household and individual\ncapacity increased through social support and social networks, which then created an enabling community\ncontext, further strengthening agency and enabling community action. This increased opportunities for healthy\nbehaviour. Community actions addressed lack of awareness about diabetes, gendered barriers to physical activity and\nlack of access to blood glucose testing. The interaction between the individual, household, and community contexts\namplified change, and yet there was limited engagement with macro level, or â??stateâ??, barriers to healthy behaviour.\nConclusions: The participatory approach enabled groups to analyse how context affected their ability to have healthy\nbehaviours and participants engaged with issues as a community in the ways that they felt comfortable. We suggest\nmeasuring health literacy and social networks in future interventions and recommend specific capacity strengthening\nto develop public accountability mechanisms and health systems strengthening to complement community-based\ninterventions....
Background: Diabetic ketoacidosis (DKA) is an acute, major, life-threatening complication of diabetes that requires\nimmediate treatment. Allergic reaction to insulin is rare, especially when using recombinant human insulin. The\nclinical presentation of insulin allergy can range from minor local symptoms to a severe generalized allergic\nreaction such as anaphylaxis. A limited number of cases have been reported on the treatment of severe DKA in\npatients with type 2 diabetes with insulin allergy. Here, we describe a patient with type 2 diabetes with insulin\nallergy in which severe DKA resolved after the initiation of continuous intravenous (IV) recombinant human insulin\ninfusion.\nCase presentation: A 58-year-old man with type 2 diabetes initiated subcutaneous insulin administration (SIA) after\nfailure of oral antidiabetic treatment. Symptoms of an allergic reaction developed, including pruritic wheals\nappearing within 10 min of injection and lasting over 24 h. Both skin prick and intradermal tests were positive with\ndifferent types of insulin. .....................................
Background: The shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict Beta-\ncell function and insulin resistance. However, there have been few studies conducted on Chinese people. Thus, we\naimed to verify the usefulness of the glucose response curve in a large Chinese population.\nMethods: A total of 9059 OGTT (3-h tests) were categorized into either a monophasic or a multiphasic group\nbased on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, the\nMatsuda Index, the insulinogenic index, and the disposition index were assessed by plasma glucose and serum\ninsulin concentration obtained at fasting or during an OGTT....................................
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